Clinical Outcome Of Gamma Knife Radiosurgery For Cavernous MalformationHa-Young Choi1, Eun-Jeong Koh11Chonbuk National University Medical School Hospital, Jeonju, Republic of Korea Keywords: gamma knife, outcome, cavernous malformation, radiosurgery, vascular malformationInteractive Manuscript
Ask Questions of this Manuscript:
What is the background behind your study?
The efficacy of gamma-knife radiosurgery (GKRS) for cavernous malformation (CM) is still controversial.
What is the purpose of your study?
We analyzed result of our series to find the efficiency of GKRS for CM.
Describe your patient group.
Between June 2006 and June 2008, 16 patients were included. Twelve patients experienced hemorrhagic event. One patient suffered from epilepsy. Three patients were incidentally diagnosed.
Describe what you did.
Mean follow up duration was 38 months.
Describe your main findings.
Average volume was 1.96 (0.06~9.9)cc. Average numbers of isocenter were 6.12 (1~19). Average marginal dose were 15.625 (15~20) Gy. In period of first 3 months 2 patients showed rebleeding. In 6 months after GKRS two patients experienced adverse radiation effect. One patient showed radiation necrosis and the other one suffered from hemiparesis. The patient who showed radiation necrosis fully recovered but patient with hemiparesis still suffered from motor grade 4 hemiparesis. Other patients did not have bleeding or adverse radiation effect.
Describe the main limitation of this study.
This is a retrospective study.
Describe your main conclusion.
Although our follow up duration is relatively short, GKRS has the effectiveness of treatment for CM.
Describe the importance of your findings and how they can be used by others.
Meticulous selection of marginal dose and highly matched conformity is necessary for good outcome.
The efficacy of gamma-knife radiosurgery (GKRS) for cavernous malformation (CM) is still controversial.
We analyzed result of our series to find the efficiency of GKRS for CM.
Between June 2006 and June 2008, 16 patients were included. Twelve patients experienced hemorrhagic event. One patient suffered from epilepsy. Three patients were incidentally diagnosed.
Mean follow up duration was 38 months.
Average volume was 1.96 (0.06~9.9)cc. Average numbers of isocenter were 6.12 (1~19). Average marginal dose were 15.625 (15~20) Gy. In period of first 3 months 2 patients showed rebleeding. In 6 months after GKRS two patients experienced adverse radiation effect. One patient showed radiation necrosis and the other one suffered from hemiparesis. The patient who showed radiation necrosis fully recovered but patient with hemiparesis still suffered from motor grade 4 hemiparesis. Other patients did not have bleeding or adverse radiation effect.
This is a retrospective study.
Although our follow up duration is relatively short, GKRS has the effectiveness of treatment for CM.
Meticulous selection of marginal dose and highly matched conformity is necessary for good outcome.
Project Roles:
H. Choi (), E. Koh ()
