An investigation of eye lens dose of stereotactic radiosurgery for benign brain tumor using Leksell gamma knife model CKeywords: gamma knife, cornea, cataract, radiation, brain tumorInteractive Manuscript
Ask Questions of this Manuscript:
What is the background behind your study?
The eye lens dose may be important in radiosurgical planning.
What is the purpose of your study?
The authors conducted a study to assess the eye lens dosimetry in benign
brain tumor treatment when using the Leksell gamma knife model C.
Describe your patient group.
Fifty consecutive patients with benign brain tumor underwent gamma knife
radiosurgery (GKRS) were evaluated with the Leksell GammaPlan system.
Describe what you did.
The ages, gender, use of plugs, numbers of plugs, tumor volume, distances from tumor to lens, side of lens, treatment time, prescription doses, and numbers of isocenters were evaluated. The ANOCOVA (Analysis of Covariance) was applied to build a predicted equation and test significant predictors
Describe your main findings.
The ages, gender, numbers of plugs, side of lens, treatment time, and numbers of isocenters were not significant predictors. The tumor volume (P=0.003), use of plugs (P<0.001), prescription doses (P=0.039), and distance from tumor to lens (P=0.001) were significant predictors to build an equation of maximum dose of eyes lens in the model (R2=0.812).
Describe the main limitation of this study.
This was a retrospective study.
Describe your main conclusion.
Patients with benign brain tumors undergoing GKRS without eye shielding may develop cataracts due to the high radiation dose to the eye lenses.
Describe the importance of your findings and how they can be used by others.
The authors suggest the routine use of bilateral eye shielding for the
patients with benign brain tumors especial for the larger size of
tumors, higher prescription doses and tumor location near the eye lens.
The eye lens dose may be important in radiosurgical planning.
The authors conducted a study to assess the eye lens dosimetry in benign
brain tumor treatment when using the Leksell gamma knife model C.
Fifty consecutive patients with benign brain tumor underwent gamma knife
radiosurgery (GKRS) were evaluated with the Leksell GammaPlan system.
The ages, gender, use of plugs, numbers of plugs, tumor volume, distances from tumor to lens, side of lens, treatment time, prescription doses, and numbers of isocenters were evaluated. The ANOCOVA (Analysis of Covariance) was applied to build a predicted equation and test significant predictors
The ages, gender, numbers of plugs, side of lens, treatment time, and numbers of isocenters were not significant predictors. The tumor volume (P=0.003), use of plugs (P<0.001), prescription doses (P=0.039), and distance from tumor to lens (P=0.001) were significant predictors to build an equation of maximum dose of eyes lens in the model (R2=0.812).
This was a retrospective study.
Patients with benign brain tumors undergoing GKRS without eye shielding may develop cataracts due to the high radiation dose to the eye lenses.
The authors suggest the routine use of bilateral eye shielding for the
patients with benign brain tumors especial for the larger size of
tumors, higher prescription doses and tumor location near the eye lens.
Project Roles:
