Long-term follow-up of gamma knife surgery for nondistensible orbital venous malformationsDong Liu1, Desheng Xu21 2Gamma Knife center, Tianjin Medical University Second Hospital Keywords: gamma knife, orbit, venous malformation, vision, outcomeInteractive Manuscript
Ask Questions of this Manuscript:
What is the background behind your study?
Orbital lesions are suitable for stereotactic radiosurgery.
What is the purpose of your study?
Our purpose was to assess the long-term results of Gamma Knife surgery (GKS) in patients with nondistensible orbital venous malformations(NOVM).
Describe your patient group.
The series included 9 men and 16 women with a median age of 18 (range 2-56) years.
Describe what you did.
Twenty-five patients with NOVM were treated with GKS between 1995 and 2005. Prior resection had been performed in 19 patients, and GKS was performed as the sole treatment option in 6 patients. Prescription peripheral dose varied from 12 to 20 Gy (mean 15.6 Gy); the corresponding central dose was 24 to 40Gy. The mean volume of the tumor at GKS was 7.6 cm3 (range, 1.0 to 30.2 cm3).
Describe your main findings.
At a median follow-up period of 56 months (range, 30 to 120 months), tumor shrinkage was observed in all patients. Visual acuity improved in 15 patients, remained stable in 8 patients (including 3 patients who were completely blind before GKS) and deteriorated in 2 cases. All patients had symptomatic improvement. Except for reversible conjunctival edema in 4 cases, no other serious acute side effect was observed.
Describe the main limitation of this study.
This was a retrospective series.
Describe your main conclusion.
Gamma Knife surgery provides long-term tumor control for NOVM.
Describe the importance of your findings and how they can be used by others.
The results of this study add substantial evidence that GKS may definitely become a standard treatment approach in selected cases of NOVM.
Orbital lesions are suitable for stereotactic radiosurgery.
Our purpose was to assess the long-term results of Gamma Knife surgery (GKS) in patients with nondistensible orbital venous malformations(NOVM).
The series included 9 men and 16 women with a median age of 18 (range 2-56) years.
Twenty-five patients with NOVM were treated with GKS between 1995 and 2005. Prior resection had been performed in 19 patients, and GKS was performed as the sole treatment option in 6 patients. Prescription peripheral dose varied from 12 to 20 Gy (mean 15.6 Gy); the corresponding central dose was 24 to 40Gy. The mean volume of the tumor at GKS was 7.6 cm3 (range, 1.0 to 30.2 cm3).
At a median follow-up period of 56 months (range, 30 to 120 months), tumor shrinkage was observed in all patients. Visual acuity improved in 15 patients, remained stable in 8 patients (including 3 patients who were completely blind before GKS) and deteriorated in 2 cases. All patients had symptomatic improvement. Except for reversible conjunctival edema in 4 cases, no other serious acute side effect was observed.
This was a retrospective series.
Gamma Knife surgery provides long-term tumor control for NOVM.
The results of this study add substantial evidence that GKS may definitely become a standard treatment approach in selected cases of NOVM.
Project Roles:
D. Liu (), D. Xu ()
